Until a year ago, geneticist Don Tillman had never had a second date.
Then he met Rosie, 'the world's most incompatible woman'. And now, living in New York, they have survived ten months of marriage. But life is still not plain sailing for Don. Not least with the sudden arrival of his best friend Gene, serial philanderer, who takes up residence on their sofa. Then Rosie drops a bombshell, and soon Don must face her hormonally induced irrational behaviour as he prepares for the biggest challenge of his life - on top of dodging deportation, prosecution and professional disgrace.